Cupids Health

What Is Chronic Fatigue Syndrome?

This video delves into the underlying mechanisms, symptoms, lifestyle and treatment associated with chronic fatigue syndrome. The purpose of this video is to educate a general audience about chronic fatigue syndrome, its diagnosis, and treatment (or lack of treatment options).

Please look at the following links to gain more information:

PACE trial reanalysis: and
PACE trail:

This video was made by Demystifying Medicine students: Sabrina Garritano, Angelica Dimita, Hayley Duff, and Desmond Chan

Copyright McMaster University 2018


Courage, K. H. (2014). Baffling chronic fatigue syndrome set for diagnostic overhaul. Scientific American. Retrieved from

Lorusso, L., Mikhalova, S. V., Capelli, E., Ferrari, D., Ngonga, G. K., & Ricevuti, G. (2008). Immunological aspects of chronic fatigue syndrome. Autoimmunity Reviews. doi:i:10.1016/j.autrev.2008.08.003

Mayo Clinic. (2018). Chronic fatigue syndrome. Retrieved from conditions/chronic-fatigue-syndrome/symptoms-causes/syc-20360490

Mayo Clinic. (2018, January 05). Chronic fatigue syndrome – Diagnosis and Treatment. Retrieved March 19, 2018, from

O’Rourke, M. (2015). A new name, and wider recognition, for chronic fatigue syndrome. The New Yorker. Retrieved from iom-report

White, P. D., Goldsmith, K. A., Johnson, A. L., Potts, L., Walwyn, R., DeCesare, J. C., … & Bavinton, J. (2011). Comparison of adaptive pacing therapy, cognitive behaviour therapy, graded exercise therapy, and specialist medical care for chronic fatigue syndrome (PACE): a randomised trial. The Lancet, 377(9768), 823-836.

Rehmeyer, J., & Tuller, D. (2017). Getting it wrong on chronic fatigue syndrome. The New York Times. Retrieved from

Rowe, P. C., Underhill, R. A., Friedman, K. J., Gurwitt, A., Medow, M. S., Schwartz, M. S., … & Rowe, K. S. (2017). Myalgic encephalomyelitis/chronic fatigue syndrome diagnosis and management in young people: a primer. Frontiers in pediatrics, 5, 121.

Wilshire, C., Kindlon, T., Matthees, A., & McGrath, S. (2017). Can patients with chronic fatigue syndrome really recover after graded exercise or cognitive behavioural therapy? A critical commentary and preliminary re-analysis of the PACE trial. Fatigue: Biomedicine, Health & Behavior, 5(1), 43-56.

Yancey, J. R., & Thomas, S. M. (2012). Chronic fatigue syndrome: diagnosis and treatment. Am Fam Physician, 86(8), 741-746.


25 thoughts on “What Is Chronic Fatigue Syndrome?

  1. I’m 20, had been diagnosed with 2 autoimmune diseases, gerd, gastritis, and asthma. Now i’m trying to figure out whether the chronic pain & fatigue that i’ve been feeling for more than a month is possibly from CFS or something else, since the symptoms are just so fitting. Going to consult soon if the pain isn’t getting better by time 🤞

  2. Nuvigil helps my CFS. Sometimes I alternate it with Concerta. This is an opinion only. I was almost narcoleptic. I also take an antidepressant & some supplements. But the supplements that have helped me the most are Vitamin D and Magnesium Biglycinate. The antidepressant really helped with my aches from fibromyalgia. This regimen helps but I’m by no means 100 percent. I like others was extremely active. I’m here looking for solutions.

  3. I think stress causes most illnesses . The body gets so low because we don’t look after it . Eating things
    we have to come to terms with happen , our bodies and minds cannot cope, we are too weak ,

    Then in later life , the knocks that the body takes are weaken and we suffer more. Take care of yourself better
    A car can work better ,if it is oiled and looked after and kept in good condition.
    remember , what you take into your body ,helps you take care of it , mentally and physically.

  4. I’ve commented here before but I just wanted to say that I have been doing very limited amounts of graded exercise therapy for a good while now and it can (at times) help me to increase my endurance. I’m saying that I will then crash and have to start all over again. I judge mine by steps per day.
    At my peak I managed 10,000 steps a day! (Once) and I though “wow! Finally I’m almost better and I’m about to start my life again.” Then I crashed again. Which has happened several times since. I’m currently struggling to get 1250 steps a day, but I won’t stop trying.
    It’s exhausting, heart breaking and it’s hard, but 20 extra steps a day can lead to a better life. Even if it only lasts a few weeks.
    I’m just never going to give in or give up.

  5. i am so tired and weak all the time, and i am only very young. i don't know how i am going to cope throughout my life because i can't do anything without feeling like i will just fall asleep. it is getting in the way of my education too and i can't focus on anything. and all that everyone says to me is that i am just lazy or that it will pass. i hope there will be a cure one day 🙁

  6. I'm 29 and I've stayed home for 19 months and only left the house 6 times out of which 4 were doctor's visits and 2 were for walks. I feel horribly fatigued even after brushing my teeth. I feel preoccupied and overwhelmed with basic tasks. Been on antidepressants and Neurotransmitter pills. I don't know how to get out of this slump. Not everyone understands me and it's very hard to follow multiple advices. I used to be fun and was on top of the world. Now I'm in a slump like burnout and friends and even family have left me. My psychiatrist is a horrible dude who thinks I'm taking it so I stopped seeing him. I don't have the zeal or even motivation to do the things I loved. Irregular sleep patterns and insomnia, loss of appetite, lack.of prayer and willingness to do things are most common. It sucks to suck so bad man!

  7. I've had CFS for over 16 years. I manage it. But one thing that needs to be understood is — at least in cases like mine — a great portion of the effect of CFS relate to the Suppression of the Recovery Portion of the Immune System CAUSED by the exhaustion. In short, it takes me 2-3x longer to recover from anything from a minor cut to a heart attack. Not only do I experience extreme exhaustion, but DURING THIS RECOVERY PERIOD I have often experienced a breakdown in other parts of my body, usually whatever is weakest or most vulnerable at the time. In the beginning, every time I over exerted myself (by doing what I had been able to do a month before), I would wake up the next day with an infection in my gums. This happened over and over, until I finally began to realize the connection. Over the years I have developed arthritis, osteoporosis, I have had heart attacks and tumors. I had the heart attack right after I had two teeth removed (this became necessary because of the gum infections). It took me almost a year and a lot of babying to recover from the operation to remove the tumor. The most recent part of my body to be effected by exhaustion has been my eyes.

    When I say I manage it, I mean I have learned to pay attention to the early signs of fatigue and rest before it becomes critical. I have learned to pace myself and always be aware of my energy level. I am still mobile and can even exercise regularly. BUT– when I first became ill I was in better-than-average condition, as I exercised daily, running approximately 5-6 miles, a day. This was nothing novel. I had run from the time I was 14 until I became ill when I was 44. I also worked on my feet in restaurants, which is an all day workout. I also avoid eating carbs and fats, as simply digesting these can exhaust me. I still walk regularly, daily if possible, and am still self-sufficient.

  8. been sick for almost all year with several different things and i get 12-15 hours of sleep, take the meds, go to therapy, etc. And yet, here i am, still sick, still tired, no energy, nothing. I work, i eat, i sleep, i repeat. Masks have become a normal because of how often im sick now.

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