Cupids Health

Scientific Evidence for Conditions that Increase Risk of Severe Illness | COVID-19


Supported by meta-analysis/systematic review Cancer Systematic Review [1, 2]
Cohort Study [3-5]
Case Series [6-8]
Case Control Study [9] Cerebrovascular disease Meta-Analysis [10-13]
Synthesis of Evidence [14]
Cohort Study [15-17] Chronic kidney disease Meta-Analysis [13, 18]
Cohort Studies [16, 19-40]
Case Series [41-43] COPD Meta-Analysis [44-46]
Systematic Review [47, 48] Diabetes mellitus, type 1 Meta-Analysis [49]
Case Series [42]
Cohort Study [15, 50-55] Diabetes mellitus, type 2 Meta-Analysis [56]
Case Series [42]
Longitudinal Study [57]
Cohort Study [49, 53, 57-62] Heart conditions (such as heart failure, coronary artery disease, or cardiomyopathies) Meta-Analysis [63-65]
Cohort Study [15, 16] Smoking, current and former Meta-Analysis [44, 64, 66-73] Obesity Meta-Analysis [74-76]
Cohort [24, 77-85] Pregnancy Systematic Review [86, 87]
Case Control [88, 89]
Case Series [90-92]
Cohort Study [93-96] Supported by mostly cohort, case-control, or cross-sectional studies (if there is a systematic review or meta-analysis available, it represents one condition in a larger category of conditions) Children with certain underlying conditions Systematic Review [97, 98]
Cross-Sectional Study [99-101]
Cohort Study [102-110]
Case Series [111, 112] Down syndrome Cohort Study [113, 114] HIV Cohort Study [32, 115-117]
Case Series [118-120] Neurologic conditions Review [121]
Cross-Sectional Study [99]
Cohort Study [16, 102] Overweight Cohort Study [80]
Case Series [85] Other lung disease (including interstitial lung disease, pulmonary fibrosis, pulmonary hypertension) Cohort [122-124] Sickle cell disease Cohort [111, 112, 125, 126]
Case Series [111, 126-141] Solid organ or blood stem cell transplantation Meta-Analysis [83]
Case Series [142-151]
Cohort [152] Substance use disorders Case-Control Study [153-155]
Cohort Study [156, 157] Use of corticosteroids or other immunosuppressive medications Cohort Study [158]
Cross Sectional [159]
Case Series [160-162] Supported by mostly case series, case reports or, if other study design, the sample size is small (and no systematic review or meta-analysis available were reviewed) Cystic fibrosis Case Series [163-165]
Cohort [166] Thalassemia Case Series [167-170]
Cross Sectional [171] Supported by mixed evidence Asthma Meta-Analysis [172-174]
Review [175]
Case Series [176]
Cohort Study [16, 40, 177-182] Hypertension Meta-Analysis [64, 183-186]
Systematic Review [187]
Cohort Study [15, 16, 19, 179, 188-194]
Case Series [195] Liver disease Meta-Analysis [196-200]
Cohort [19, 28, 41, 201-215]
Case-Control [216-221]
Cross sectional [222]
Case Series [223-225] Immune deficiencies Meta-Analysis [226]
Cohort [227-229]
Case Series [142, 143, 151, 230-235]



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