Bipolar Disorder is a chronic and complex mental health disorder that causes extreme mood swings, including periods of extreme lows (depression) and extreme highs (mania or hypomania). In this video, we will discuss what Bipolar Disorder is, the symptoms of manic, hypomanic, and depressive episodes, and comparing the difference between Bipolar Disorder Type 1 and Type 2. Also, we will discuss the biological aspect of Bipolar Disorder by introducing two key hormones – Serotonin and Dopamine. We want to raise the public awareness of mental health issues, and emphasize the importance of seeking a health care professional if you or anyone you know is suffering from a mental health crisis.
This video was made by McMaster Demystifying Medicine students Mark Bertone, Jasmine Leung, Teja Koi and Maha Arif.
Copyright McMaster University 2021.
Ashok, A. H., Marques, T. R., Jauhar, S., Nour, M. M., Goodwin, G. M., Young, A. H., & Howes, O. D. (2017). The dopamine hypothesis of bipolar affective disorder: the state of the art and implications for treatment. Molecular psychiatry, 22(5), 666–679. https://doi.org/10.1038/mp.2017.16
Chiang, K. J., Tsai, J. C., Liu, D., Lin, C. H., Chiu, H. L., & Chou, K. R. (2017). Efficacy of cognitive-behavioral therapy in patients with bipolar disorder: A meta-analysis of randomized controlled trials. PloS one, 12(5), e0176849. https://doi.org/10.1371/journal.pone.0176849
Cittolin-Santos, G. F., Fredeen, J. C., & Cotes, R. O. (2017). A Case Report of Mania and Psychosis Five Months after Traumatic Brain Injury Successfully Treated Using Olanzapine. Case reports in psychiatry, 2017, 7541307. https://doi.org/10.1155/2017/7541307
Dailey MW, Saadabadi A. Mania. [Updated 2020 Nov 20]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2020 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK493168/
Geddes, J. R., & Miklowitz, D. J. (2013). Treatment of bipolar disorder. Lancet (London, England), 381( 9878), 1672–1682. https://doi.org/10.1016/S0140-6736(13)60857-0
Jain A, Mitra P. Bipolar Affective Disorder. [Updated 2020 Oct 19]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2020 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK558998/
Koçbıyık, S., Batmaz, S., & Turhan, L. (2016). A Case in the Bipolar Spectrum. Noropsikiyatri arsivi, 53( 1), 80–82. https://doi.org/10.5152/npa.2015.9999
Mahmood, T., & Silverstone, T. (2001). Serotonin and bipolar disorder. Journal of affective disorders, 66( 1), 1-11.
Manji, H. K., Quiroz, J. A., Payne, J. L., Singh, J., Lopes, B. P., Viegas, J. S., & Zarate, C. A. (2003). The underlying neurobiology of bipolar disorder. World psychiatry : official journal of the World Psychiatric Association (WPA), 2( 3), 136–146.
McCormick, U., Murray, B., & McNew, B. (2015). Diagnosis and treatment of patients with bipolar disorder: A review for advanced practice nurses. Journal of the American Association of Nurse Practitioners, 27(9), 530–542. https://doi.org/10.1002/2327-6924.12275
Park, S., Park, B., Koh, M. K., & Joo, Y. H. (2014). Case report: bipolar disorder as the first manifestation of CADASIL. BMC psychiatry, 14( 1), 175.
Phillips, M. L., & Kupfer, D. J. (2013). Bipolar disorder diagnosis: challenges and future directions. Lancet (London, England), 381(9878), 1663–1671. https://doi.org/10.1016/S0140-6736(13)60989-7
Tran, D. Q., Beaudry, V., & Lajoie, Y. (2013). First Manic Episode in an 11-Year-Old Girl.
Journal of the Canadian Academy of Child and Adolescent Psychiatry = Journal de l’Académie canadienne de psychiatrie de l’enfant et de l’adolescent, 22(4), 324–326.